Yes have a great trip and please report back with some figures.
So just got back after completing 390 miles in the day. Pretty happy with how it went. Did 65mph on ACC on the long motorway runs, got 3.5 miles per kWh on the way there and 3.3 miles per kWh on the way back which meant my calcs were pretty good.
Charging kind of went ok, first charge was seamless at Tesla Trentham Gardens in Stoke, paid 32p. In the evening I planned to charge at Tesla Trafford Centre and get dinner whilst charging to 100% but unfortunately they were full and there was a disorganised queue and I wasn't going to get into arguments so I parked up, went for something to eat then came back and there were bays available. Luckily I needed to get some supermarlet shopping for my daughter so we went to Asda over the road and by the time we had finished the car was at 100%, paid 38p there.
So charging costs during the trip were £21.81 + £14.22 used from start 100% - 20% remaining at end £5.37 = £30.66, I think that's probably about £20 under what I would have done it in my Merc diesel.
These costs are pretty good value for money, unlike the £18 return I paid for M6 Toll + the parking ticket I got in the peak district

(my own fault, stuck the back wheels just onto double yellows as there was nowhere to park).
Vibration wasn't a problem at 65, you could feel it from time to time as the ACC increased power up hills but it wasn't enough to bother me. Checked modes etc and as has previously been proved, it makes no differences what mode (i.e. which wheels are running) it's in.
Overall I was happy with comfort, except the bottom of the seat that digs in my back when I have jeans on. No aches or pains after 10 hours driving the XP today. If I wasn't on 8000 miles a year I'd probably do more long trips based on my experiences today.